May 14, 1804

The Lewis and Clark Expedition sets out across Missouri. William Clark and Meriwether Lewis led their 45-man crew out of St. Charles to explore the lands west of the Mississippi River. The team returned to St. Louis about two years later, on September 23, 1806.

Based upon content from the book Missouri 365: This Day in Missouri History by John W. Brown, broadcaster and Missouri historian. Get your copy at Reedy Press.

Photo—Adobe Stock